A debuff is a temporary negative perk. Sometimes, a debuff can last multiple in-game days, or simply a few seconds. They can include loss of vision, slower movement speed, freezing, taking more damage, and so on. Debuffs can be acquired by picking up or equipping cursed items, such as the Cursed Family Man Doll or one of Sadness' balloons. However, certain enemies, such as Terror Vision or The Harbringer, give debuffs just by being near the player or battling them. If the player is a certain race, has certain traits, or certain items, some debuffs will not be able to affect them. Other debuff can be applied by spells.
List of Debuffs: